Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival

29 Aug 2002

Abstract excerpt

In order to gain further insights into the role of the p16 gene in cell cycle regulation and the prognostic implications of its inactivation, we investigated the methylation status of the p16 gene in 98 untreated patients using a polymerase chain reaction assay based on the inability of some restriction enzymes to digest methylated sequences. Forty-one patients showed a p16 methylated gene (42%). The percentage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways
Share to Multiple Myeloma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12199782
DOI: 10.1046/j.1365-2141.2002.03749.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survivalPMID 12199782Read ↗

Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implicationsSemantic proximity Read ↗

Frequent Hypermethylation of p16 and p15 Genes in Multiple MyelomaSemantic proximity Read ↗

p16 INK4a andp15INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significanceSemantic proximity Read ↗

Detecting methylation patterns of <i>p16</i>, <i>MGMT</i>, <i>DAPK</i> and <i>E‐cadherin</i> genes in multiple myeloma patientsSemantic proximity Read ↗

DNA‐methylation analysis identifies the E‐cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathiesSemantic proximity Read ↗

Analysis of MTHFR polymorphisms and P16 methylation and their correlation with clinical-biological features of multiple myeloma.Semantic proximity Read ↗

Hypermethylation of the p16 gene in normal oral mucosa of smokersSemantic proximity Read ↗

Frequent inactivation of thep16 gene in human pituitary tumors by gene methylationSemantic proximity Read ↗

Methylation of p15 and p16 Genes in Acute Promyelocytic Leukemia: Potential Diagnostic and Prognostic SignificanceSemantic proximity Read ↗

Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.Semantic proximity Read ↗

p16 (INK4<sup><i>a</i></sup>, MTS‐1) gene polymorphism and methylation status in human pituitary tumoursSemantic proximity Read ↗

Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.