Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detecting methylation patterns of <i>p16</i>, <i>MGMT</i>, <i>DAPK</i> and <i>E‐cadherin</i> genes in multiple myeloma patients

3 Mar 2009

Abstract excerpt

Multiple myeloma (MM) is a B-cell neoplasia characterized by the clonal proliferation of plasma cells. Besides known genetic abnormalities, epigenetic changes are also known to effect MM pathogenesis. DNA methylation is an epigenetic mechanism that silences genes by adding methyl groups to cytosine-guanine dinucleotides at the promoter regions. In this study, the methylation status of four genes; p16, O6-methyl...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research
Share to Multiple Myeloma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19302404
DOI: 10.1111/j.1751-553x.2009.01146.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detecting methylation patterns of <i>p16</i>, <i>MGMT</i>, <i>DAPK</i> and <i>E‐cadherin</i> genes in multiple myeloma patientsPMID 19302404Read ↗

DNA‐methylation analysis identifies the E‐cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathiesSemantic proximity Read ↗

The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myelomaSemantic proximity Read ↗

Aberrant p15, p16, p53, and DAPK Gene Methylation in Myelomagenesis: Clinical and Prognostic ImplicationsSemantic proximity Read ↗

<i>TGFβR2</i> aberrant methylation is a potential prognostic marker and therapeutic target in multiple myelomaSemantic proximity Read ↗

Aberrant DNA methylation in multiple myeloma: A major obstacle or an opportunity?Semantic proximity Read ↗

Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implicationsSemantic proximity Read ↗

Epigenetic Aberrations in Multiple MyelomaSemantic proximity Read ↗

Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma.Semantic proximity Read ↗

DNA Methylation Analysis Determines the High Frequency of Genic Hypomethylation and Low Frequency of Hypermethylation Events in Plasma Cell TumorsSemantic proximity Read ↗

Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myelomaSemantic proximity Read ↗

Frequent Hypermethylation of p16 and p15 Genes in Multiple MyelomaSemantic proximity Read ↗

Blood-derived cell-free DNA is a superior biomarker for noninvasive DNA methylation profiling in multiple myelomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.