Article
Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility.
Neurology - 27 Aug 2002
Malm H, Kajantie E, Kivirikko S, Kääriäinen H, Peippo M, Somer M
Abstract excerpt
The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay. Generally, only a small proportion of prenatally exposed children are affected. The authors describe three families in whom the occurrence of FVS in all the siblings strongly suggests hereditary susceptibility to valproic acid-induced adverse outcome. The risk for...
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