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Article

In utero exposure to valproate increases the risk of isolated cleft palate

25 Sept 2015

Abstract excerpt

INTRODUCTION: Orofacial clefting (OFC) has been described in infants exposed to valproic acid (VPA) prenatally, but often no distinction is made between cleft lip and palate (CLP) and isolated cleft palate (ICP). This distinction is important as these conditions have different management implications and the distinction has implications too for understanding the teratogenic mechanisms. METHODS: We searched...

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PMID: 26408639
DOI: 10.1136/archdischild-2015-308278

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