Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gain modulation from background synaptic input.

Neuron - 15 Aug 2002

Chance Frances S, Abbott L F, Reyes Alex D

Abstract excerpt

Gain modulation is a prominent feature of neuronal activity recorded in behaving animals, but the mechanism by which it occurs is unknown. By introducing a barrage of excitatory and inhibitory synaptic conductances that mimics conditions encountered in vivo into pyramidal neurons in slices of rat somatosensory cortex, we show that the gain of a neuronal response to excitatory drive can be modulated by varying the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Artifacts
Share to Electric Stimulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Neurological

Share to Neural Inhibition

Share to Neural Pathways

Share to Organ Culture Techniques

Share to Somatosensory Cortex

Source

Identifiers

PMID: 12194875
DOI: 10.1016/s0896-6273(02)00820-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Gain modulation from background synaptic input.PMID 12194875Read ↗

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneuronsSemantic proximity Read ↗

Adaptation and inhibition control pathological synchronization in a model of focal epileptic seizureSemantic proximity Read ↗

The discharge variability of neocortical neurons during high-conductance states.Semantic proximity Read ↗

Bayesian modeling of BAC firing as a mechanism for apical amplification in neocortical pyramidal neuronsSemantic proximity Read ↗

Low-rate firing limit for neurons with axon, soma and dendrites driven by spatially distributed stochastic synapsesSemantic proximity Read ↗

Estimating Excitatory and Inhibitory Synaptic Conductances from Spike Trains using a Recursive Bayesian ApproachSemantic proximity Read ↗

All-optical electrophysiology reveals behavior-dependent dynamics of excitation and inhibition in the hippocampusSemantic proximity Read ↗

Changes in neural network homeostasis trigger neuropsychiatric symptoms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.