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Article

Similarities and differences in the in vivo response of mouse neonatal gonocytes and spermatogonia to genotoxic stress.

Biology of reproduction - 1 May 2009

Forand Anne, Fouchet Pierre, Lahaye Jean-Baptiste, Chicheportiche Alexandra, Habert René, Bernardino-Sgherri Jacqueline

Abstract excerpt

Neonatal gonocytes are the precursors of both spermatogonial stem cells and spermatogonia; thus, any persistent DNA damage in these cells may lead to heritable mutations. We investigated the response of male mouse neonatal germ cells to ionizing radiation. Both gonocytes and spermatogonia died in large numbers by apoptosis. However, we found that the gonocytes were significantly more sensitive than spermatogonia...

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Identifiers

PMID: 19144961
DOI: 10.1095/biolreprod.108.072884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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