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Article

Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes.

Oncogene - 5 May 2005

Toyoshima Megumi, Shimura Tsutomu, Adiga Satish-Kumar, Taga Masataka, Shiraishi Kazunori, Inoue Masao, Yuan Zhi-Min, Niwa Ohtsura

Abstract excerpt

Cell cycle arrest in response to DNA damage is important for the maintenance of genomic integrity in higher eukaryotes. We have previously reported the novel p53-dependent S-phase checkpoint operating in mouse zygotes fertilized with irradiated sperm. In the present study, we analysed the detail of the p53 function required for this S-phase checkpoint in mouse zygotes. The results indicate that ATM kinase is...

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Identifiers

PMID: 15735681
DOI: 10.1038/sj.onc.1208514

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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