Article
The Decorin gene 179 allelic variant is associated with a slower progression of renal disease in patients with type 1 diabetes.
Nephron - 1 Sept 2002
De Cosmo S, Tassi V, Thomas S, Piras G P, Trevisan R, Cavallo Perin P, Bacci S, Zucaro L, Cisternino C, Trischitta V, Viberti G C
Abstract excerpt
UNLABELLED: Background genetic factors may influence the variability in the rate of progression of kidney disease in type 1 diabetes. In diabetes, progressive mesangial matrix expansion and glomerular sclerosis are, to a large extent, mediated by TGF-beta1. Decorin, a proteoglycan which is a component of the extracellular matrix, regulates TGF-beta1 activity and expression. We have examined the relationship...
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