Article
ACE, PAI-1, decorin and Werner helicase genes are not associated with the development of renal disease in European patients with type 1 diabetes.
Diabetes/metabolism research and reviews - 1 Jan 2000
De Cosmo S, Margaglione M, Tassi V, Garrubba M, Thomas S, Olivetti C, Piras G P, Trevisan R, Vedovato M, Cavallo Perin P, Bacci S, Colaizzo D, Cisternino C, Zucaro L, Di Minno G, Trischitta V, Viberti G C
Abstract excerpt
BACKGROUND: Genetic factors are involved in the development of diabetic nephropathy in Type 1 diabetes. We have examined the association of four candidate genes, angiotensin converting enzyme (ACE): insertion/deletion (I/D) polymorphism, plasminogen activator inhibitor-1 (PAI-1): 4G/5G polymorphism, decorin: 179/183/185 polymorphism and Werner syndrome helicase: C/R polymorphism, with the presence of diabetic...
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