Mutation in 23S rRNA associated with macrolide resistance in Neisseria gonorrhoeae.

doi:10.1128/AAC.46.9.3020-3025.2002

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Article

Mutation in 23S rRNA associated with macrolide resistance in Neisseria gonorrhoeae.

Antimicrobial agents and chemotherapy - 1 Sept 2002

Ng Lai-King, Martin Irene, Liu Gary, Bryden Louis

Abstract excerpt

Fifty-six azithromycin-resistant (MICs, 2.0 to 4.0 micro g/ml) Neisseria gonorrhoeae strains with cross-resistance to erythromycin (MICs, 2.0 to 64.0 micro g/ml), isolated in Canada between 1997 and 1999, were characterized, and their mechanisms of azithromycin resistance were determined. Most (58.9%) of them belonged to auxotype-serotype class NR/IB-03, with a 2.6-mDa plasmid. Based on resistance to crystal...

Topics

Anti-Bacterial Agents
Azithromycin
Canada
DNA, Bacterial
Drug Resistance
Erythromycin
Gonorrhea
Humans
Microbial Sensitivity Tests
Mutation
Neisseria gonorrhoeae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Conformation

Oligonucleotide Probes

Peptidyl Transferases

RNA, Ribosomal, 23S

Reverse Transcriptase Polymerase Chain Reaction

Transformation, Bacterial

Source

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Identifiers

PMID: 12183262
DOI: 10.1128/AAC.46.9.3020-3025.2002
PMCID: PMC127397

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