Article
[Resistance to azithromycin of Neisseria gonorrhoeae strains isolated in Poland in 2012-2013 years].
Medycyna doswiadczalna i mikrobiologia - 1 Jan 2014
Młynarczyk-Bonikowska Beata, Kujawa Marlena, Młynarczyk Grażyna, Malejczyk Magdalena, Majewski Sławomir
Abstract excerpt
INTRODUCTION: Azithromycin is one of the most commonly used macrolide antibiotics. As other macrolides it inhibits bacterial proteins synthesis by binding with V domene of bacterial 23S rRNA. Resistance to azithromycin can be related to: 1. Mutations in gene encoding 23S rRNA. Significant effect on azithromycin MIC (minimal inhibitory concentration) is not observed when the mutation occurs only in 1 allele. In...
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