Article
Microsatellite instability in intestinal- and diffuse-type gastric carcinoma.
The Journal of pathology - 1 Jun 1997
Buonsanti G, Calistri D, Padovan L, Luinetti O, Fiocca R, Solcia E, Ranzani G N
Abstract excerpt
To investigate the role of genetic instability in the development of intestinal- and diffuse-type gastric cancers, six microsatellite loci were analysed in 98 carcinomas of the two main histotypes, at both early and advanced stages of progression, and in five preneoplastic lesions. RER+ phenotype frequency proved to be significantly higher (P = 0.013) in intestinal (23 per cent) than in diffuse cancers (5 per...
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