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Article

Efficient generation of antigen-specific cytotoxic T cells using retrovirally transduced CD40-activated B cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2002

Kondo Eisei, Topp Max S, Kiem Hans-Peter, Obata Yuichi, Morishima Yasuo, Kuzushima Kiyotaka, Tanimoto Mitsune, Harada Mine, Takahashi Toshitada, Akatsuka Yoshiki

Abstract excerpt

The development of rapid, efficient, and safe methods for generating Ag-specific T cells is necessary for the clinical application of adoptive immunotherapy. We show that B cells stimulated with CD40 ligand and IL-4 (CD40-B cells) can be efficiently transduced with retroviral vectors encoding a model Ag, CMV tegument protein pp65 gene, and maintain high levels of costimulatory molecules after gene transfer. CTL...

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Share to Antigen Presentation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to T-Lymphocytes, Cytotoxic

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Identifiers

PMID: 12165546
DOI: 10.4049/jimmunol.169.4.2164

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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