Article
Simultaneous activation of viral antigen-specific memory CD4+ and CD8+ T-cells using mRNA-electroporated CD40-activated autologous B-cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000
Van den Bosch Glenn A, Van Gulck Ellen, Ponsaerts Peter, Nijs Griet, Lenjou Marc, Apers Ludwig, Kint Ilse, Heyndrickx Leo, Vanham Guido, Van Bockstaele Dirk R, Berneman Zwi N, Van Tendeloo Viggo F I
Abstract excerpt
Recently, it has become obvious that not only CD8 T-cells, but also CD4 T-helper cells are required for the induction of an effective, long-lasting cellular immune response. In view of the clinical importance of cytomegalovirus (CMV) and human immunodeficiency virus (HIV) infection, we developed...
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