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Article

VEGF‐mediated fusion in the generation of uniluminal vascular spheroids

24 Sept 2008

Abstract excerpt

Embryonic mouse allantoic tissue (E8.5) was cultured in hanging drops to generate a three-dimensional vascular micro-tissue. The resulting tissue spheroids had an inner network of small diameter vessels expressing platelet endothelial cell adhesion molecule-1 (PECAM-1) and an outer layer of cells expressing SMalphaA, SM22-alpha, and SM-MHC. In a subsequent phase of culture, the fusion-promoting activity of...

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PMID: 18816835
DOI: 10.1002/dvdy.21720

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