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Use of a Chimeric Adenovirus Vector Enhances BMP2 Production and Bone Formation

20 Jul 2002

Abstract excerpt

Recombinant adenoviral vectors have potential for the treatment of a variety of musculoskeletal defects and such gene therapy systems have been a recent research focus in orthopedic surgery. In studies reported here, two different adenovirus vectors have been compared for their ability to transduce human bone marrow mesenchymal stem cells (hBM-MSCs) and elicit bone formation in vivo. Vectors consisted either of...

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PMID: 12162816
DOI: 10.1089/104303402760128568

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