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Gene Therapy Approaches for Bone Regeneration

1 Jan 2004

Abstract excerpt

Gene therapy represents a promising approach for delivering regenerative molecules to specific tissues including bone. Several laboratories have shown that virus-based BMP expression vectors can stimulate osteoblast differentiation and bone formation in vivo. Both in vivo and ex vivo transduction of cells can induce bone formation at ectopic and orthotopic sites. Adenovirus and direct DNA delivery of genes...

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PMID: 14745239
DOI: 10.1159/000075031

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