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Article

Leukocyte Diapedesis In Vivo Induces Transient Loss of Tight Junction Protein at the Blood–Retina Barrier

24 Jun 2005

Abstract excerpt

PURPOSE: Although much is now understood about the molecular structure of tight junctions (TJs), little is known about the regulation of their function during neural inflammatory disease processes in vivo. The mechanisms by which leukocytes transmigrate the blood-retina barrier (BRB) without affecting endothelial permeability are controversial. METHODS: Confocal immunofluorescence microscopy of ex vivo retinal...

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PMID: 15980240
DOI: 10.1167/iovs.04-1333

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