Article
Angiotensin converting enzyme insertion allele in relation to high altitude adaptation.
Annals of human genetics - 1 Nov 2001
Qadar Pasha M A, Khan A P, Kumar R, Grover S K, Ram R B, Norboo T, Srivastava K K, Selvamurthy W, Brahmachari S K
Abstract excerpt
Angiotensin converting enzyme (ACE) gene I/D polymorphism has been associated with high altitude (HA) disorders as well as physical performance. We, however, envisage that the polymorphism may be associated with adaptation to the hypobaric hypoxia of altitude, thus facilitating physical performance. For this purpose, three unrelated adult male groups, namely (1) the Ladakhis (HLs), who reside at and above a...
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