The role of PC-1 and ACE genes in diabetic nephropathy in type 1 diabetic patients: evidence for a polygenic control of kidney disease progression.

doi:10.1093/ndt/17.8.1402

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The role of PC-1 and ACE genes in diabetic nephropathy in type 1 diabetic patients: evidence for a polygenic control of kidney disease progression.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Aug 2002

De Cosmo Salvatore, Miscio Giuseppe, Zucaro Luigi, Margaglione Maurizio, Argiolas Alessandra, Thomas Stephen, Piras Giampiero, Trevisan Roberto, Perin Paolo Cavallo, Bacci Simonetta, Frittitta Lucia, Pizzuti Antonio, Tassi Vittorio, Di Minno Giovanni, Viberti Giancarlo, Trischitta Vincenzo

Abstract excerpt

BACKGROUND: The DD genotype of the ACE gene predisposes to faster diabetic nephropathy (DN) progression but its role in DN development is more controversial. We reported previously, in type 1 diabetic patients, an association between faster DN progression and the PC-1 gene Q121 variant, which associates with insulin resistance in non-diabetic subjects. We investigated here whether the combination of the ACE DD...

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PMID: 12147786
DOI: 10.1093/ndt/17.8.1402

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The role of PC-1 and ACE genes in diabetic nephropathy in type 1 diabetic patients: evidence for a polygenic control of kidney disease progression.PMID 12147786Read ↗

ACE and PC-1 gene polymorphisms in normoalbuminuric Type 1 diabetic patients: a 10-year prospective study.Semantic proximity Read ↗

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