Article
STAT3 down-regulates the expression of cyclin D during liver development.
The Journal of biological chemistry - 27 Sept 2002
Matsui Takaaki, Kinoshita Taisei, Hirano Toshio, Yokota Takashi, Miyajima Atsushi
Abstract excerpt
As the expression of cyclin D1 is induced during liver regeneration and also in hepatic tumor cells, cyclin D1 is likely to play an important role in the proliferation and transformation of hepatocytes. However, the role of cyclin D1 in liver development remains unknown. Here we show that the expression of D-type cyclins including cyclin D1, D2, and D3 is down-regulated along with liver development. In addition,...
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