Article
Asp1080 upstream of the calmodulin-binding domain is critical for autoinhibition of hPMCA4b.
The Journal of biological chemistry - 27 Sept 2002
Pászty Katalin, Penheiter Alan R, Verma Anil K, Padányi Rita, Filoteo Adelaida G, Penniston John T, Enyedi Agnes
Abstract excerpt
The role of the plasma membrane Ca(2+) pump (PMCA) is to remove excess Ca(2+) from the cytosol to maintain low intracellular Ca(2+) levels. Asp(1080) lies within an acidic sequence between the C-terminal inhibitory region and the catalytic core of PMCAs and is part of the caspase-3 recognition site of isoform 4b. Caspase-3 cuts immediately after this residue and activates the pump by removing the inhibitory...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.