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Article

Hyperactivation of the human plasma membrane Ca2+ pump PMCA h4xb by mutation of Glu99 to Lys.

The Journal of biological chemistry - 11 Apr 2014

Mazzitelli Luciana R, Adamo Hugo P

Abstract excerpt

The transport of calcium to the extracellular space carried out by plasma membrane Ca(2+) pumps (PMCAs) is essential for maintaining low Ca(2+) concentrations in the cytosol of eukaryotic cells. The activity of PMCAs is controlled by autoinhibition. Autoinhibition is relieved by the binding of Ca(2+)-calmodulin to the calmodulin-binding autoinhibitory sequence, which in the human PMCA is located in the C-terminal...

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Identifiers

PMID: 24584935
DOI: 10.1074/jbc.M113.535583
PMCID: PMC4036192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hyperactivation of the human plasma membrane Ca2+ pump PMCA h4xb by mutation of Glu99 to Lys.PMID 24584935Read ↗

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Asp1080 upstream of the calmodulin-binding domain is critical for autoinhibition of hPMCA4b.Semantic proximity Read ↗

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