Article
Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995
Venturelli D, Martinez R, Melotti P, Casella I, Peschle C, Cucco C, Spampinato G, Darzynkiewicz Z, Calabretta B
Abstract excerpt
Chronic myelogenous leukemia evolves in two clinically distinct stages: a chronic and a blast crisis phase. The molecular changes associated with chronic phase to blast crisis transition are largely unknown. We have identified a cDNA clone, DR-nm23, differentially expressed in a blast-crisis cDNA...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Base Sequence
- Cell Differentiation
- Cell Line
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Gene Expression
- Granulocytes
- Hematopoietic Stem Cells
- Humans
- Mice