Article
Differential lipid binding of truncation mutants of Galleria mellonella apolipophorin III.
Biochemistry - 30 Jul 2002
Dettloff Matthias, Niere Marc, Ryan Robert O, Luty Robert, Kay Cyril M, Wiesner Andreas, Weers Paul M M
Abstract excerpt
Apolipophorin III (apoLp-III) is a prototype exchangeable apolipoprotein that is amenable to structure-function studies. The protein folds as a bundle of five amphipathic alpha-helices and undergoes a dramatic conformational change upon lipid binding. Recently, we have shown that a truncation mutant of Galleria mellonella apoLp-III comprising helices 1-3 is stable in solution and able to bind to lipid surfaces...
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