Article
Essential role of the conformational flexibility of helices 1 and 5 on the lipid binding activity of apolipophorin-III.
The Journal of biological chemistry - 7 Sept 2001
Soulages J L, Arrese E L, Chetty P S, Rodriguez V
Abstract excerpt
It has been recently postulated that the conformational flexibility of helices 1 and 5 of Locusta migratoria apoLp-III could play an important role in early steps of binding of this apolipoprotein to a lipid surface (Soulages, J. L., and Arrese, E. L. (2000) J. Biol. Chem. 275, 17501-17509). To test this model, we have designed a double Cys mutant in which a disulfide bond linking helices 1 and 5 could be formed,...
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