Article
Identification of hepatitis C virus core domain inducing suppression of allostimulatory capacity of dendritic cells.
Archives of pharmacal research - 1 Jun 2002
Kim Ho Sang, Lee Jae Kwon, Yang In Ho, Ahn Jeong Keun, Oh Yoon-I, Kim Chul Joong, Kim Young Sang, Lee Chong-Kil
Abstract excerpt
Hepatitis C virus (HCV) is remarkably efficient at establishing chronic infection. One of the reasons for this appears to be the suppression of the accessory cell function of professional antigen presenting cells. In the present study, the immunosuppressive activity of HCV protein was examined on dendritic cells (DCs) generated from mouse bone marrow progenitor cells in vitro. We found that the DCs forced to...
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