Kaposi's Sarcoma-Associated Herpesvirus-Induced Upregulation of the c-<i>kit</i>Proto-Oncogene, as Identified by Gene Expression Profiling, Is Essential for the Transformation of Endothelial Cells

doi:10.1128/jvi.76.16.8383-8399.2002

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Kaposi's Sarcoma-Associated Herpesvirus-Induced Upregulation of the c-<i>kit</i>Proto-Oncogene, as Identified by Gene Expression Profiling, Is Essential for the Transformation of Endothelial Cells

28 Jul 2002

Abstract excerpt

Kaposi's sarcoma (KS), the most frequent malignancy afflicting AIDS patients, is characterized by spindle cell formation and vascularization. Infection with KS-associated herpesvirus (KSHV) is consistently observed in all forms of KS. Spindle cell formation can be replicated in vitro by infection of dermal microvascular endothelial cells (DMVEC) with KSHV. To study the molecular mechanism of this transformation,...

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PMID: 12134042
DOI: 10.1128/jvi.76.16.8383-8399.2002

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