Article
gamma-Interferon produced by CD8+ T cells infiltrating Kaposi's sarcoma induces spindle cells with angiogenic phenotype and synergy with human immunodeficiency virus-1 Tat protein: an immune response to human herpesvirus-8 infection?
Blood - 1 Feb 1998
Fiorelli V, Gendelman R, Sirianni M C, Chang H K, Colombini S, Markham P D, Monini P, Sonnabend J, Pintus A, Gallo R C, Ensoli B
Abstract excerpt
Kaposi's sarcoma (KS) is an angioproliferative disease associated with infection by the human herpesvirus-8 (HHV-8). HHV-8 possesses genes including homologs of interleukin-8 (IL-8) receptor, Bcl-2, and cyclin D, which can potentially transform the host cell. However, the expression of these gene...
Topics
- Animals
- CD8-Positive T-Lymphocytes
- Drug Synergism
- Endothelium, Vascular
- Gene Products, tat
- HIV-1
- HLA-DR Antigens
- Herpesviridae Infections
- Herpesvirus 8, Human
- Humans
- Interferon-gamma
- Macrophages
- Mice