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Article

The colonic response to genotoxic carcinogens in the rat: regulation by dietary fibre

1 Jul 2002

Abstract excerpt

The apoptotic response to DNA damage appears to be an innate biological mechanism for protection against tumourigenesis. It is possible that agents that protect against colorectal cancer act by enhancing the apoptotic deletion of cells suffering DNA damage, with consequent removal of those with tumourigenic mutations. We examined the acute apoptotic response to genotoxic carcinogens ("AARGC") in colonic...

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PMID: 12117770
DOI: 10.1093/carcin/23.7.1131

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