Article
T locus shows no evidence for linkage disequilibrium or mutation in American Caucasian neural tube defect families.
American journal of medical genetics - 1 Jul 2002
Speer Marcy C, Melvin Elizabeth C, Viles Kristi D, Bauer Kim A, Rampersaud Evadnie, Drake Courtney, George Timothy M, Enterline David S, Mackey Joanne F, Worley Gordon, Gilbert John R, Nye Jeffery S
Abstract excerpt
We investigated the T locus as a candidate gene in a series of patients and families with lumbosacral myelomeningocele. Single-strand conformation polymorphism (SSCP) analysis was used to identify sequence variation in all 8 exons and in intron 7 of this locus. We found evidence of substantial polymorphism within this locus, as previously reported [Papapetrou et al., 1999, J Med Genet 36:208-213], and moderately...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.