Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group.

Clinical genetics - 1 Aug 1999

Speer M C, Nye J, McLone D, Worley G, Melvin E C, Viles K D, Franklin A, Drake C, Mackey J, George T M

Abstract excerpt

Neural tube defects are a common, complex disorder with genetic and environmental components to risk. We investigated the previously reported interaction between homozygosity for the thermolabile variant at the methylenetetrahydrofolate reductase and heterozygosity for the 844ins68 allele at the cystathionine beta-synthase loci in cases with lumbosacral myelomeningocele and their parents. Using control allele...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Cystathionine beta-Synthase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homozygote

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Neural Tube Defects

Share to Odds Ratio

Share to Oxidoreductases Acting on CH-NH Group Donors

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 10517251
DOI: 10.1034/j.1399-0004.1999.560208.x

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group.PMID 10517251Read ↗

Interaction of folate and homocysteine pathway genotypes evaluated in susceptibility to neural tube defects (NTD) in a German population.Semantic proximity Read ↗

Updated investigations of the role of methylenetetrahydrofolate reductase in human neural tube defects.Semantic proximity Read ↗

Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.Semantic proximity Read ↗

Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects.Semantic proximity Read ↗

The thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) is not a major risk factor for neural tube defect in American Caucasians. The NTD Collaborative Group.Semantic proximity Read ↗

5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects.Semantic proximity Read ↗

The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother.Semantic proximity Read ↗

Polymorphisms of 5,10-methylenetetrahydrofolate reductase and cystathionine beta-synthase genes as a risk factor for neural tube defects in Sétif, Algeria.Semantic proximity Read ↗

Deep sequencing study of the MTHFR gene to identify variants associated with myelomeningocele.Semantic proximity Read ↗

Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population.Semantic proximity Read ↗

Polymorphisms of 5,10-Methylenetetrahydrofolate reductase and cystathionine beta-synthase genes as a risk factor for neural tube defects in Sétif, Algeria. Concerning the article by Houcher et al., Pediatr Neurosurg 2009;45:472-477.Semantic proximity Read ↗

Role of parental folate pathway single nucleotide polymorphisms in altering the susceptibility to neural tube defects in South India.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.