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Article

The Orphan Nuclear Receptor NR4A1 Regulates Insulin-Like 3 Gene Transcription in Leydig Cells1

20 Oct 2005

Abstract excerpt

Insulin-like 3 (INSL3) is a hormone produced by fetal and adult Leydig cells of the testis and by theca and luteal cells of the adult ovary. In males, INSL3 regulates testicular descent during fetal life, whereas in adults, it acts as a germ cell survival factor. In the ovary, INSL3 regulates oocyte maturation. Despite its importance for male sex differentiation and reproductive function in both sexes, very...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16237153
DOI: 10.1095/biolreprod.105.044560

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