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Rescue of infertile transgenic rat lines by intracytoplasmic injection of cryopreserved round spermatids

21 May 2002

Abstract excerpt

Transgenic male rats carrying human alpha-lactalbumin with thymidine kinase gene (line name; LAC3) were found to be infertile due to expression of the transgene in the testes. Furthermore, it was not possible to maintain the line even by the use of intracytoplasmic sperm injection (ICSI). Therefore, round spermatids prepared from the LAC3 rats were microinjected into strontium-activated oocytes using a...

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PMID: 12112591
DOI: 10.1002/mrd.10127

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