Fate of microinjected spermatid mitochondria in the mouse oocyte and embryo

Abstract excerpt

Mouse round spermatids labelled with MitoTracker were microinjected into Sr(2+)-activated mouse oocytes. The labelled mitochondria were tracked up to the morula/blastocyst stage using fluorescence microscopy. The overall incidence of embryos with labelled mitochondria fell from 80% in the 1-cell zygote to 25% in 2-cell, 9% in 4-cell and approximately 1% in 8-cell or later stages. Thus it appears that almost all...

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