Article
Autoimmune lymphoproliferative syndrome associated with severe humoral immunodeficiency and monoclonal gammopathy.
Annals of hematology - 1 Jun 2002
Nanan R, Ströbel P, Haas J-P, Marx A, Kreth H W
Abstract excerpt
A boy of Caucasian origin with a new subtype of autoimmune lymphoproliferative syndrome (ALPS) is described. The clinical picture was dominated by chronic noninfectious lymphadenopathy, splenomegaly, and recurrent bacterial infections. At the age of 6 the patient died of pneumococcal meningitis. Laboratory investigation disclosed impaired apoptosis in both B- and T-lymphocyte subsets and expanded populations of...
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