Article
Polymorphism in the tumor necrosis factor-alpha gene in women with preeclampsia.
Journal of assisted reproduction and genetics - 1 May 2002
Heiskanen Jaana, Romppanen Eeva-Liisa, Hiltunen Mikko, Iivonen Susan, Mannermaa Arto, Punnonen Kari, Heinonen Seppo
Abstract excerpt
PURPOSE: We determined whether genetic variability in the gene encoding for tumor necrosis factor-alpha (TNF-alpha) contributes to individual differences in susceptibility to the development of preeclampsia. METHODS: The study involved 133 preeclamptic and 115 healthy control pregnant women who were genotyped for C-850T polymorphism in the TNF-alpha gene promoter. Chi-square analysis was used to assess genotype...
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