Article
Inhibitor development in previously untreated patients with hemophilia A: a prospective long-term follow-up comparing plasma-derived and recombinant products.
Seminars in thrombosis and hemostasis - 1 Jun 2002
Kreuz Wolfhart, Ettingshausen Carmen Escuriola, Zyschka Alex, Oldenburg Johannes, Saguer Inmaculada Martinez, Ehrenforth Silke, Klingebiel Thomas
Abstract excerpt
In order to assess inhibitor development in previously untreated patients (PUPs) with severe (factor VIII [FVIII]<1%) and moderate (FVIII 1 to 5%) hemophilia A, a prospective study was initiated in 1976. During the 23-year study period, 72 hemophiliacs were frequently exposed prophylactically or...
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