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Article

Type and intensity of FVIII exposure on inhibitor development in PUPs with haemophilia A. A patient-level meta-analysis.

Thrombosis and haemostasis - 1 May 2015

Marcucci Maura, Mancuso Maria Elisa, Santagostino Elena, Kenet Gili, Elalfy Mohssen, Holzhauer Susanne, Bidlingmaier Christoph, Escuriola Ettingshausen Carmen, Iorio Alfonso, Nowak-Göttl Ulrike

Abstract excerpt

The impact of treatment-related factors on inhibitor development in previously untreated patients (PUPs) with haemophilia A is still debated. We present the results of a collaborative, individual patient data meta-analytic project. Eligible data sources were published cohorts of PUPs for which patient-level data were available. The exposures of interest were factor (F)VIII type (recombinant [rFVIII] vs...

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PMID: 25631402
DOI: 10.1160/TH14-07-0621

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