Article
Treatment related factors and inhibitor development in children with severe haemophilia A.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 Mar 2011
Maclean P S, Richards M, Williams M, Collins P, Liesner R, Keeling D M, Yee T, Will A M, Young D, Chalmers E A
Abstract excerpt
With the advent of modern factor replacement therapy the most important remaining obstacle to successful treatment in haemophilia A is the development of inhibitory antibodies against Facto VIII (FVIII). This retrospective case control study examined genetic variables and early treatment patterns in severe haemophilia A patients who subsequently developed clinically significant inhibitors to FVIII compared with...
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