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Article

Mutation of the catalytic domain of the foamy virus reverse transcriptase leads to loss of processivity and infectivity.

Journal of virology - 1 Aug 2002

Rinke Carolyn S, Boyer Paul L, Sullivan Mark D, Hughes Stephen H, Linial Maxine L

Abstract excerpt

Foamy virus (FV) replication is resistant to most nucleoside analog reverse transcriptase (RT) inhibitors. In an attempt to create a 2',3'-dideoxy-3'-thiacytidine (3TC)-sensitive virus, the second residue in the highly conserved YXDD motif of simian foamy virus-chimpanzee (human isolate) [SFVcpz(...

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Identifiers

PMID: 12097569
DOI: 10.1128/jvi.76.15.7560-7570.2002
PMCID: PMC136390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12097569-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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