Article
The antiretroviral activity of APOBEC3 is inhibited by the foamy virus accessory Bet protein.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2005
Löchelt Martin, Romen Fabian, Bastone Patrizia, Muckenfuss Heide, Kirchner Nadine, Kim Yong-Boum, Truyen Uwe, Rösler Uwe, Battenberg Marion, Saib Ali, Flory Egbert, Cichutek Klaus, Münk Carsten
Abstract excerpt
Genome hypermutation of different orthoretroviruses by cellular cytidine deaminases of the APOBEC3 family during reverse transcription has recently been observed. Lentiviruses like HIV-1 have acquired proteins preventing genome editing in the newly infected cell. Here we show that feline foamy virus (FFV), a typical member of the foamy retrovirus subfamily Spumaretrovirinae, is also refractory to genome...
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