Article
In vitro fidelity of the prototype primate foamy virus (PFV) RT compared to HIV-1 RT.
Virology - 25 Oct 2007
Boyer Paul L, Stenbak Carolyn R, Hoberman David, Linial Maxine L, Hughes Stephen H
Abstract excerpt
We compared the in vitro fidelity of wild-type human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) and the prototype foamy virus (PFV) RT. Both enzymes had similar error rates for single nucleotide substitutions; however, PFV RT did not appear to make errors at specific hotspots, like HIV-1 RT. In addition, PFV RT made more deletions and insertions than HIV-1 RT. Although the majority of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.