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Article

Mutational analysis of the reverse transcriptase and ribonuclease H domains of the human foamy virus.

Nucleic acids research - 25 Jul 1995

Kögel D, Aboud M, Flügel R M

Abstract excerpt

Human foamy or spuma virus (HFV) codes for a distinct set of pol gen products. To determine the minimal requirements for the HFV enzymatic activities, defined residues of the reverse transcriptase (RT) and ribo-nuclease H (RNase H) domain of the HFV pol gene were mutated by site-specific PCR mutagenesis. The mutant gene products were bacterially expressed, purified by Ni2+ chelate affinity chromatography and...

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Identifiers

PMID: 7544460
DOI: 10.1093/nar/23.14.2621
PMCID: PMC307083

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