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Article

Nucleolar localization of an isoform of the IGF-I precursor

2 Jul 2002

Abstract excerpt

BACKGROUND Alternative exons encode different isoforms of the human insulin-like growth factor-I (IGF-I) precursor without altering mature IGF-I. We hypothesized that the various IGF-I precursors may traffic IGF-I differently. Chimeric IGF-I precursors were made with green fluorescent protein (GFP) cloned between the signal and mature IGF-I domains. RESULTS Chimeras containing exons 1 or 2 were located in the...

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PMID: 12095420
DOI: 10.1186/1471-2121-3-17

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