Article
An approach for global scanning of single nucleotide variations.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2002
Pan Xinghua, Weissman Sherman M
Abstract excerpt
Efficient global scanning of single nucleotide variations in DNA sequences between related, complex DNA samples remains a challenge. In the present article we present an approach to this problem. We have used immobilized thymidine DNA glycosylases to capture and enrich DNA fragments containing internal mismatched base pairs and separate these fragments as a pool from perfectly base-paired fragments as another...
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