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Article

GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway.

The EMBO journal - 1 Jul 2002

Clavería Cristina, Caminero Eva, Martínez-A Carlos, Campuzano Sonsoles, Torres Miguel

Abstract excerpt

Grim encodes a protein required for programmed cell death in Drosophila. The Grim N-terminus induces apoptosis by disrupting IAP blockage of caspases; however, N-terminally-deleted Grim retains pro apoptotic activity. We describe GH3, a 15 amino acid internal Grim domain absolutely required for i...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12093734
DOI: 10.1093/emboj/cdf354
PMCID: PMC126101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12093734-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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