Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

grim promotes programmed cell death of Drosophila microchaete glial cells.

Mechanisms of development - 1 Jan 2000

Wu Julie N, Nguyen Nguyen, Aghazarian Maral, Tan Ying, Sevrioukov Evgueni A, Mabuchi Megumu, Tang Wei, Monserrate Jessica P, White Kristin, Brachmann Carrie Baker

Abstract excerpt

The Inhibitor of apoptosis (IAP) antagonists Reaper (Rpr), Grim and Hid are central regulators of developmental apoptosis in Drosophila. Ectopic expression of each is sufficient to trigger apoptosis, and hid and rpr have been shown to be important for programmed cell death (PCD). To investigate t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Lineage
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Embryo, Nonmammalian

Share to Neuroglia

Share to Neuropeptides

Share to Proto-Oncogene Proteins c-bcl-2

Source

Open in PubMed Open full text

Identifiers

PMID: 20558283
DOI: 10.1016/j.mod.2010.06.001
PMCID: PMC2956798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20558283-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

grim promotes programmed cell death of Drosophila microchaete glial cells.PMID 20558283Read ↗

reaper is required for neuroblast apoptosis during Drosophila development.Semantic proximity Read ↗

Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila.Semantic proximity Read ↗

GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway.Semantic proximity Read ↗

The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death.Semantic proximity Read ↗

The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers.Semantic proximity Read ↗

A Bax/Bak-independent mitochondrial death pathway triggered by Drosophila Grim GH3 domain in mammalian cells.Semantic proximity Read ↗

Control of apoptosis by Drosophila DCAF12.Semantic proximity Read ↗

Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis.Semantic proximity Read ↗

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function.Semantic proximity Read ↗

Drosophila sickle Is a Novel grim-reaper Cell Death ActivatorSemantic proximity Read ↗

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.Semantic proximity Read ↗

Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.