Crossover clustering and rapid decay of linkage disequilibrium in the Xp/Yp pseudoautosomal gene SHOX.

doi:10.1038/ng918

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Article

Crossover clustering and rapid decay of linkage disequilibrium in the Xp/Yp pseudoautosomal gene SHOX.

Nature genetics - 1 Jul 2002

May Celia A, Shone Angela C, Kalaydjieva Luba, Sajantila Antti, Jeffreys Alec J

Abstract excerpt

Crossover between the human sex chromosomes during male meiosis is restricted to the terminal pseudoautosomal pairing regions. An obligatory exchange occurs in PAR1, an Xp/Yp pseudoautosomal region of 2.6 Mb, which creates a male-specific recombination 'hot domain' with a recombination rate that is about 20 times higher than the genome average. Low-resolution analysis of PAR1 suggests that crossovers are...

Topics

Base Sequence
Crossing Over, Genetic
Diploidy
Genetic Variation
Genotype
Haplotypes
Heterozygote
Homeodomain Proteins
Humans
Linkage Disequilibrium
Male
Meiosis
Mutation
Polymorphism, Single Nucleotide
Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 12089524
DOI: 10.1038/ng918

Genes

SHOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Short Stature Homeobox Protein

Spermatozoa