Article
Multipoint linkage map of the human pseudoautosomal region, based on single-sperm typing: do double crossovers occur during male meiosis?
American journal of human genetics - 1 Sept 1994
Schmitt K, Lazzeroni L C, Foote S, Vollrath D, Fisher E M, Goradia T M, Lange K, Page D C, Arnheim N
Abstract excerpt
Sperm typing was used to measure recombination fractions among pseudoautosomal markers and the beginning of the X/Y-specific sequences located at the pseudoautosomal boundary. These experiments included primer-extension preamplification and PCR followed by allele typing using gel electrophoresis. A newly developed data-analysis program allowed the construction of the first multipoint-linkage sperm-typing map,...
Topics
- Alleles
- Base Sequence
- Chromosome Mapping
- Crossing Over, Genetic
- DNA Fingerprinting
- DNA Primers
- Genetic Linkage
- Genetic Markers
- Humans
- Likelihood Functions